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ea0013oc38 | British Thyroid Association Award | SFEBES2007

The novel thyroid hormone derivative 3-iodothyronamine increases food intake via the hypothalamic arcuate nucleus

White Nicholas , Dhillo Waljit , Bewick Gavin , Gardiner James , Scutt James , Thompson Emily , Kokkinos Alexander , Armstrong Alan , Ghatei Mohammad , Bloom Stephen

3-iodothyronamine (T1AM) is a novel, endogenous rapid acting biogenic amine, which is a potent agonist of the G-protein coupled trace amine-associated receptor 1, TAAR1. It has been suggested that endogenous T1AM could be generated by enzymatic deiodonation and decarboxylation of T4. The presence of T1AM in rat brain and the distribution of the TAAR1 receptor in the hypothalamus suggest that T1AM may affect food intake and regulate e...

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ea0013oc17 | Novartis Clinical Endocrinology Award | SFEBES2007

Kisspeptin-54 potently stimulates luteinising hormone release during the preovulatory phase of the menstrual cycle in healthy human females.

Chaudhri Owais , Dhillo Waljit , Thompson Emily , Murphy Kevin , Salem Victoria , Patterson Michael , Donaldson Mandy , Amber Vian , Ramachandran Radha , Nijher Gurjinder , Kokkinos Alexander , Ghatei Mohammad , Bloom Steve

Kisspeptin, the endogenous ligand of the GPR54 receptor, is a key regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null mice exhibit reproductive dysfunction and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates and human males. The effects of kisspeptin administration to human females are not known.Aim: To investigate the effects of kisspeptin on luteinising hormone (LH) release during the menstrual cycle in fema...

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ea0013np2 | Novartis Prize posters | SFEBES2007

Kisspeptin-54 potently stimulates luteinising hormone release during the preovulatory phase of the menstrual cycle in healthy human females

Chaudhri Owais , Dhillo Waljit , Thompson Emily , Murphy Kevin , Salem Victoria , Patterson Michael , Donaldson Mandy , Amber Vian , Ramachandran Radha , Nijher Gurjinder , Kokkinos Alexander , Ghatei Mohammad , Bloom Steve

(This poster is based on OC17)...

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Endocrine Abstracts

The novel thyroid hormone derivative 3-iodothyronamine increases food intake via the hypothalamic arcuate nucleus

Kisspeptin-54 potently stimulates luteinising hormone release during the preovulatory phase of the menstrual cycle in healthy human females.

Kisspeptin-54 potently stimulates luteinising hormone release during the preovulatory phase of the menstrual cycle in healthy human females

BiosciAbstracts